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=0.001). The median overall survival was 12.3 months (95% CI, 9.5 to 15.2; 242 deaths) with sacituzumab govitecan and 11.5 months (95% CI, 8.6 to 13.6; 212 deaths) with chemotherapy (hazard ratio for death, 0.90; 95% CI, 0.77 to 1.07; P
=0.25). The most common adverse events in the sacituzumab govitecan group were neutropenia (63.8% vs. 7.0%), diarrhea (13.1% vs. 4.0%), fatigue (6.9% vs. 2.6%), and nausea (6.3% vs. 0.9%). The most common grade 3 to 4 adverse events were neutropenia (23.1% vs. 3.5%) and diarrhea (15.7% vs. 0.9%) in the sacituzumab govitecan group; and neutropenia (36.2% vs. 2.6%), febrile neutropenia (9.3% vs. 0%), and thrombocytopenia (7.3% vs. 0%) in the chemotherapy group.
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