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Do not use this medication if you have asthma (an inflammation of the airways), a heart condition such as angina (or chest pain), high blood pressure, blood clots, or have had a stroke. There may be an increased risk of these problems with this medication. Do not use any other type of hormonal birth control (such as the patch or the ring), such as in combination with the pill. In addition, do not use birth control pills if you are breastfeeding or plan to. Ask your doctor before using this medication.
This paper reports a case-control study of a group of Iranian patients with diffuse malignant mesothelioma. Patients enrolled in the study included those from 1) Khorasan region where there is a high prevalence of the disease and 2) those from Mashhad, the capital of Khorasan province, where no case-control study had been conducted thus far. Simian virus 40 (SV40) DNA was detected in 63% of the patients' tumors versus 43% of the controls by PCR and Southern blotting. The odds ratio of developing mesothelioma after an infection with SV40 was 4.4 (95% CI, 2.1 to 10.1), P value for trend = 0.001. There was no association between SV40 and histological subtypes of mesothelioma, but the odds ratio was significant in pleural mesothelioma for SV40-positive patients versus SV40-negative patients in both regions (3.9, 95% CI, 1.0 to 14.5).
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